The purpose of this review is to highlight noteworthy advancements in the field of capillary gel electrophoresis for the separation and analysis of proteins from the period of 2015-2021. This review will provide an overview of the historical perspective and principles of the technique, introduce the challenges and limitations commonly faced, and highlight the advancements made to overcome these issues and broaden our knowledge of the method. Finally, applications of capillary gel electrophoresis and future directions for the technique will be presented.