Noninvasive glucose monitoring using Raman spectroscopy (Conference Presentation)

Although Raman spectroscopy has shown some promise for noninvasive glucose monitoring, the absence of the characteristic Raman peaks and true prospective prediction have been criticized. Here, we present experimental data that may finalize the long debate. We present the results of direct observation of glucose-specific Raman peaks in swine glucose clamping experiments. From the measured spectra, we confirm the presence of the glucose signal and the linearity between intensities of the glucose Raman peaks and the reference glucose concentrations. Prospective prediction was achieved by simply tracking glucose Raman peak intensities.