交互感受
平衡
背景(考古学)
骨骼肌
骨重建
神经科学
生物
内分泌学
感知
古生物学
作者
Xiao Lv,Feng Gao,Xu Cao
出处
期刊:Cell Metabolism
[Elsevier]
日期:2022-12-01
卷期号:34 (12): 1914-1931
被引量:21
标识
DOI:10.1016/j.cmet.2022.09.025
摘要
Accumulating evidence indicates that interoception maintains proper physiological status and orchestrates metabolic homeostasis by regulating feeding behaviors, glucose balance, and lipid metabolism. Continuous skeletal remodeling consumes a tremendous amount of energy to provide skeletal scaffolding, support muscle movement, store vital minerals, and maintain a niche for hematopoiesis, which are processes that also contribute to overall metabolic balance. Although skeletal innervation has been described for centuries, recent work has shown that skeletal metabolism is tightly regulated by the nervous system and that skeletal interoception regulates bone homeostasis. Here, we provide a general discussion of interoception and its effects on the skeleton and whole-body metabolism. We also discuss skeletal interoception-mediated regulation in the context of pathological conditions and skeletal pain as well as future challenges to our understanding of these process and how they can be leveraged for more effective therapy.
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