Comparison of Mirabegron plus Tamsulosin and Tamsulosin Monotherapy for the Treatment of Ureteral Stent-Related Symptoms: A Prospective Randomized Study

坦索罗辛 医学 米拉贝格伦 泌尿科 支架 止痛药 碎石术 外科 麻醉 膀胱过度活动 内科学 病理 替代医学 增生
作者
Kai Zhang,Wei Yan,Hongbo Li,Jie Chen,Qian Wang,Yali Chai,Lihua Yuan,Gang Zhu
出处
期刊:Urologia Internationalis [Karger Publishers]
卷期号:106 (12): 1226-1232 被引量:1
标识
DOI:10.1159/000526607
摘要

<b><i>Introduction:</i></b> The aim of this study was to compare the efficacy of mirabegron plus tamsulosin to tamsulosin monotherapy in terms of ureteral stent-related discomfort after ureteroscopic lithotripsy. <b><i>Methods:</i></b> A total of 102 patients undergoing ureteroscopic lithotripsy and silicone ureteral stent placement were enrolled in this study. Patients were randomized 1:1 to receive either tamsulosin 0.4 mg once daily or mirabegron 50 mg + tamsulosin 0.4 mg once daily during the stenting period. Before the operation, the IPSS, QOL, and pain score were collected. On the day of ureteral stent removal, the USSQ, analgesic usage amount was collected and recorded. <b><i>Results:</i></b> The median USSQ-body pain score in the tamsulosin group and tamsulosin + mirabegron group was 15 and 16, respectively (<i>p</i> = 0.530). The median analgesic usage in the two groups was 3 and 2, respectively (<i>p</i> = 0.170). The median USSQ-urinary symptoms, USSQ-general health, USSQ-work performance, USSQ-sexual matters, and USSQ-additional problems in the two groups were 26 and 26 (<i>p</i> = 0.194), 11 and 12 (<i>p</i> = 0.068), 12 and 13 (<i>p</i> = 0.105), 2 and 2 (<i>p</i> = 0.437), 9 and 9 (<i>p</i> = 0.533), respectively. The international patients used more analgesics than Chinese patients (6 vs. 1, <i>p</i> = 0.015). <b><i>Conclusion:</i></b> Compared to tamsulosin alone, tamsulosin + mirabegron showed no additional benefit on the ureteral stent-related pain control after ureteroscopic lithotripsy and silicone stent placement. There was no significant difference on the analgesic usage and USSQ scores between the two groups. Chinese patients request fewer analgesics than international patients.
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