Facile Fabrication of Dendritic Mesoporous SiO2@CdTe@SiO2 Fluorescent Nanoparticles for Bioimaging

A seeded watermelon‐like mesoporous nanostructure (mSiO 2 @CdTe@SiO 2 , mSQS) composed of a novel dendritic mesoporous silica core, fluorescent CdTe quantum dots (QDs), and a protective solid silica shell is successfully fabricated by loading QDs into dendritic mesoporous silica nanoparticles through electrostatic interaction, and then coating with a solid silica shell by the modified Stöber method. The shell thickness of mSQS can be tuned from 0 to 32 nm as desired by controlling the reaction parameters, including the amount of silica precursor, tetraethyl orthosilicate, that is introduced, the solvent ratio (H 2 O:ethanol), and the amount of catalyst (NH 3 ⋅H 2 O). These fluorescent mSiO 2 @QDs@SiO 2 nanoparticles possess excellent stability and thickness‐dependent cytotoxicity, and are successfully applied to bioimaging.