Copper‐Catalyzed Oxidative 1,2‐Alkylarylation of Styrenes with Unactivated C(sp3)‐H Alkanes and Electron‐Rich Aromatics via C(sp3)‐H/C(sp2)‐H Functionalization

Abstract We have disclosed an alkenes dicarbofunctionalization method to introduce alkyl and electron‐rich aryl across the C=C bond of styrenes under copper catalyst and oxidative conditions, leading to construct C( sp 3 )‐C( sp 2 )/C( sp 3 )‐C( sp 3 ) bonds via dual C−H functionalization. This method realizes the synthesis of 1,1‐diarylalkanes, which are very important skeleton in natural products and drug molecules, through the grafting of electron‐rich aromatics, including indoles, pyrroles, trisubstituted aromatic. magnified image