高脂血症
发病机制
小RNA
脂代谢紊乱
生物信息学
脂质代谢
医学
生物
胆固醇
免疫学
内科学
基因
遗传学
内分泌学
血脂
糖尿病
作者
Yu Xiang,Mao Li,Meiling Zuo,Gui‐Lin Song,Liming Tan,Zhong‐Bao Yang
摘要
Hyperlipidemia is a common metabolic disorder with high morbidity and mortality, which brings heavy burden on social. Understanding its pathogenesis and finding its potential therapeutic targets are the focus of current research in this field. In recent years, an increasing number of studies have proved that miRNAs play vital roles in regulating lipid metabolism and were considered as promising therapeutic targets for hyperlipidemia and related diseases. It is demonstrated that miR-191, miR-222, miR-224, miR-27a, miR-378a-3p, miR-140-5p, miR-483, and miR-520d-5p were closely associated with the pathogenesis of hyperlipidemia. In this review, we provide brief overviews about advances in miRNAs in hyperlipidemia and its potential clinical application value.
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