微生物
生物
细菌
动物健康
生物技术
分离(微生物学)
生物降解
毒理
微生物学
生态学
遗传学
动物科学
作者
Anne Caroline Schoch Marques Pinto,Camilla Reginatto De Pierri,Alberto Gonçalves Evangelista,Ana Silvia de Lara Pires Batista Gomes,Fernando Bittencourt Luciano
出处
期刊:Toxins
[MDPI AG]
日期:2022-01-25
卷期号:14 (2): 90-90
被引量:48
标识
DOI:10.3390/toxins14020090
摘要
Deoxynivalenol (DON) is a toxic secondary metabolite produced by fungi that contaminates many crops, mainly wheat, maize, and barley. It affects animal health, causing intestinal barrier impairment and immunostimulatory effect in low doses and emesis, reduction in feed conversion rate, and immunosuppression in high doses. As it is very hard to completely avoid DON’s production in the field, mitigatory methods have been developed. Biodegradation has become a promising method as new microorganisms are studied and new enzymatic routes are described. Understanding the common root of bacteria with DON degradation capability and the relationship with their place of isolation may bring insights for more effective ways to find DON-degrading microorganisms. The purpose of this review is to bring an overview of the occurrence, regulation, metabolism, and toxicology of DON as addressed in recent publications focusing on animal production, as well as to explore the enzymatic routes described for DON’s degradation by microorganisms and the phylogenetic relationship among them.
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