Hyperuricaemia is an important risk factor of the erectile dysfunction: A systematic review and meta‐analysis

AndrologiaEarly View e14384 ORIGINAL ARTICLE Hyperuricaemia is an important risk factor of the erectile dysfunction: A systematic review and meta-analysis Wenting Wang, Wenting Wang Department of Intensive Care Unit, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSearch for more papers by this authorZhaohai Jing, Zhaohai Jing Department of Endocrinology, People's Hospital of Rizhao, Rizhao, ChinaSearch for more papers by this authorWei Liu, Wei Liu Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSearch for more papers by this authorLin Zhu, Lin Zhu Department of Endocrinology, Dong E Hospital Affiliated to Shandong First Medical University, Liaocheng, ChinaSearch for more papers by this authorHongsheng Ren, Corresponding Author Hongsheng Ren hongsheng-ren@163.com Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Correspondence Hongsheng Ren, Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: hongsheng-ren@163.com Xu Hou, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: 15153285655@163.comSearch for more papers by this authorXu Hou, Corresponding Author Xu Hou 15153285655@163.com Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Correspondence Hongsheng Ren, Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: hongsheng-ren@163.com Xu Hou, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: 15153285655@163.comSearch for more papers by this author Wenting Wang, Wenting Wang Department of Intensive Care Unit, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSearch for more papers by this authorZhaohai Jing, Zhaohai Jing Department of Endocrinology, People's Hospital of Rizhao, Rizhao, ChinaSearch for more papers by this authorWei Liu, Wei Liu Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSearch for more papers by this authorLin Zhu, Lin Zhu Department of Endocrinology, Dong E Hospital Affiliated to Shandong First Medical University, Liaocheng, ChinaSearch for more papers by this authorHongsheng Ren, Corresponding Author Hongsheng Ren hongsheng-ren@163.com Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Correspondence Hongsheng Ren, Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: hongsheng-ren@163.com Xu Hou, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: 15153285655@163.comSearch for more papers by this authorXu Hou, Corresponding Author Xu Hou 15153285655@163.com Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Correspondence Hongsheng Ren, Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: hongsheng-ren@163.com Xu Hou, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Email: 15153285655@163.comSearch for more papers by this author First published: 07 February 2022 https://doi.org/10.1111/and.14384 Funding information: This work was supported by the Shandong Provincial Research and Development Plan (grant number 2016 GSF 201052, sponsor: Hongsheng Ren); the Natural Science Foundation of China (grant number #81770774, sponsor: Xu Hou). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Serum uric acid can affect endothelial function, and hyperuricaemia-induced endothelial dysfunction is involved in the pathogenesis of cardiovascular diseases. As endothelial dysfunction is also a main pathogenic mechanism of erectile dysfunction (ED), the present study aims to evaluate the relationship between hyperuricaemia and ED via systemic review and meta-analysis. Five cohort studies and six cross-sectional studies on hyperuricaemia and ED, including a total of 454,510 participants, were recruited. Odds ratio (OR) and the 95% confidence intervals (CI) were adopted to estimate the relationship between hyperuricaemia and ED. Overall risk on effects of urate-lowering therapy (ULT) were analysed. In addition, subgroup analyses on study design, populations, age stratification and the object were conducted. In the patients with hyperuricaemia, the risk of ED was 1.59-fold higher than (pooled OR = 1.59, 95% CI [1.29, 1.97]) the non-hyperuricaemia counterparts. Urate-lowing therapy (ULT) in these hyperuricaemia patients reduced the risk of ED by 27% (OR = 1.27, 95% CI [1.14, 1.41]). After subgroup analysis, the association between hyperuricaemia and ED remained significant apart from the >60 years subgroup. Hyperuricaemia is an important risk factor of ED, while ULT can reduce the risk of ED in hyperuricaemia. This study suggests that hyperuricaemia-associated endothelial dysfunction may also underlie the pathogenesis of ED in these patients. Open Research DATA AVAILABILITY STATEMENT All data are fully available in the article and supplementary materials without restriction. Supporting Information Filename Description and14384-sup-0001-FigS1-S3.docxWord 2007 document , 463.3 KB Fig S1-S3 and14384-sup-0002-TableS1-S4.docxWord 2007 document , 26.6 KB Table S1-S4 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Early ViewOnline Version of Record before inclusion in an issuee14384 RelatedInformation