肾细胞癌
医学
揭穿
肾癌
入射(几何)
疾病
肾切除术
肿瘤科
癌症
外科
内科学
肾
重症监护医学
卵巢癌
光学
物理
作者
Umberto Capitanio,Francesco Montorsi
出处
期刊:The Lancet
[Elsevier]
日期:2016-02-01
卷期号:387 (10021): 894-906
被引量:804
标识
DOI:10.1016/s0140-6736(15)00046-x
摘要
The diagnosis and management of renal cell carcinoma have changed remarkably rapidly. Although the incidence of renal cell carcinoma has been increasing, survival has improved substantially. As incidental diagnosis of small indolent cancers has become more frequent, active surveillance, robot-assisted nephron-sparing surgical techniques, and minimally invasive procedures, such as thermal ablation, have gained popularity. Despite progression in cancer control and survival, locally advanced disease and distant metastases are still diagnosed in a notable proportion of patients. An integrated management strategy that includes surgical debulking and systemic treatment with well established targeted biological drugs has improved the care of patients. Nevertheless, uncertainties, controversies, and research questions remain. Further advances are expected from translational and clinical studies.
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