肿胀 的
壳聚糖
化学
自愈水凝胶
葡萄糖醛酸
海藻酸钙
控制释放
冷冻干燥
色谱法
多糖
材料科学
高分子化学
纳米技术
钙
有机化学
生物化学
复合材料
作者
Xiaoqing Ding,Yibin Xu,Yuanyuan Wang,Lingyu Xie,Shuang Liang,Danlei Li,Yongxia Wang,Jiangshui Wang,Xiuan Zhan
标识
DOI:10.1016/j.carbpol.2022.119438
摘要
In this study, we developed (W1/O/W2) double emulsions encapsulated by calcium-alginate hydrogel beads system (ACGs) for intestinal-targeted delivery of probiotics (Lactobacillus reuteri). Firstly, the carboxymethyl konjac glucomannan-chitosan (CMKGM-CS) nanogels were successfully fabricated by EDC/NHS initiated crosslinking, as concluded from the TEM images, FTIR spectra, XRD, etc. Then, double emulsions were prepared and encapsulated with various concentrations of alginate to form ACGs hydrogel beads. In vitro probiotic release experiments showed the lyophilized ACG-2 and ACG-3 hydrogel beads had a sustained release in simulated intestinal fluid (SIF), the viability of cells exceeded 107 CFU/mL at 6 h. The lyophilized ACG-3 hydrogel beads exhibited the viable release amount of 8.4 × 107 CFU/mL after storage for 90 d at 4 °C. Besides, the alginate concentration in the ACGs hydrogel beads influences the swelling behavior and structure of hydrogel beads by affecting the hydrogen bonds between alginate and CMKGM-CS, thereby mediating the release of probiotics.
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