微泡
成骨细胞
脂多糖
小RNA
骨免疫学
细胞生物学
炎症
化学
免疫系统
骨质疏松症
外体
骨吸收
内分泌学
内科学
免疫学
医学
生物
兰克尔
体外
生物化学
激活剂(遗传学)
基因
受体
作者
Sheng Wang,Qian Zhang,Li Wang,Hua Zhou,Gaozhi Li,Liqun Xu,Zebing Hu,Xinsheng Cao,Fei Shi,Shu Zhang
标识
DOI:10.1007/s00223-022-00977-x
摘要
Osteoimmunology focuses on the intermodulation between bone and the immune system. Lipopolysaccharide (LPS)-induced bone loss models are commonly used to investigate the interface between inflammation and osteoporosis. Circulating exosomes can regulate physiological and pathological processes through exosomal microRNAs and proteins. In this study, we observed reduced osteoblast number and bone formation in LPS-induced bone loss mice (LPS mice). Levels of circulating exosomes were increased by ~ twofold in LPS mice, and the expression of exosomal miRNAs was significantly changed. miRNAs (miRNA-125b-5p, miRNA-132-3p, and miRNA-214-3p) that were reported to inhibit osteoblast activity were significantly increased in the serum exosomes and bone tissues of LPS mice. Additionally, LPS-induced increases in exosomes significantly inhibited the osteogenic differentiation of MC3T3-E1 cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI