疾病
医学
冲程(发动机)
神经科学
重症监护医学
病理
心理学
工程类
机械工程
作者
Christos Tapeinos,Han Gao,Tomás Bauleth‐Ramos,Hélder A. Santos
出处
期刊:Small
[Wiley]
日期:2022-03-20
卷期号:18 (36)
被引量:37
标识
DOI:10.1002/smll.202200291
摘要
Abstract Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic stroke are the leading causes of death worldwide, resulting in 16% and 11% of deaths globally. Although several therapeutic approaches are presented over the years, the continuously increasing mortality rates suggest the need for more advanced strategies for their treatment. One of these strategies lies in the use of stimuli‐responsive biomaterials. These “smart” biomaterials can specifically target the diseased tissue, and after “reading” the altered environmental cues, they can respond by altering their physicochemical properties and/or their morphology. In this review, the progress in the field of stimuli‐responsive biomaterials for CCVDs in the last five years, aiming at highlighting their potential as early‐stage therapeutics in the preclinical scenery, is described.
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