纳米颗粒
磁共振成像
生物相容性
胶束
分子成像
纳米技术
材料科学
磁性纳米粒子
芯(光纤)
表面改性
核磁共振
溶解度
壳体(结构)
体内
化学
生物物理学
水溶液
有机化学
物理化学
复合材料
医学
物理
生物技术
生物
放射科
冶金
作者
Hisashi Matsushita,Shin Mizukami,Fuminori Sugihara,Yosuke Nakanishi,Yoshichika Yoshioka,Kazuya Kikuchi
标识
DOI:10.1002/ange.201308500
摘要
Abstract 19 F magnetic resonance imaging ( 19 F MRI) is useful for monitoring particular signals from biological samples, cells, and target tissues, because background signals are missing in animal bodies. Therefore, highly sensitive 19 F MRI contrast agents are in great demand for their practical applications. However, we have faced the following challenges: 1) increasing the number of fluorine atoms decreases the solubility of the molecular probes, and 2) the restriction of the molecular mobility attenuates the 19 F MRI signals. Herein, we developed novel multifunctional core–shell nanoparticles to solve these issues. They are composed of a core micelle filled with liquid perfluorocarbon and a robust silica shell. These core–shell nanoparticles have superior properties such as high sensitivity, modifiability of the surface, biocompatibility, and sufficient in vivo stability. By the adequate surface modifications, gene expression in living cells and tumor tissue in living mice were successfully detected by 19 F MRI.
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