Relationship between epicardial adipose tissue and coronary artery stenoses on computed tomography in patients scheduled for carotid artery revascularization

医学 心脏病学 内科学 血脂异常 射血分数 冠状动脉疾病 血运重建 狭窄 动脉 计算机断层血管造影 放射科 血管造影 心力衰竭 疾病 心肌梗塞
作者
Yoshihiro Sato,Hideki Kawai,Meiko Hoshino,Shoji Matsumoto,Motoharu Hayakawa,Akiyo Sadato,Masayoshi Sarai,Sadako Motoyama,Hiroshi Takahashi,Hiroyuki Naruse,Junnichi Ishii,Hiroshi Toyama,Yukio Ozaki,Ichiro NAKAHARA,Yuichi Hirose,Hideo Izawa
出处
期刊:Journal of Cardiology [Elsevier BV]
卷期号:79 (5): 588-595 被引量:2
标识
DOI:10.1016/j.jjcc.2021.12.008
摘要

We aimed to clarify the relationship between epicardial adipose tissue (EAT) volume and the presence of severe stenoses (SS) on coronary computed tomography angiography (CTA) for risk stratification of the patients with carotid artery stenoses.We prospectively performed CTA for 125 consecutive patients (72.4 ± 8.1 years, 85% men) without a history of coronary artery disease (CAD), who were scheduled for carotid artery revascularization from 2014 to 2020. SS was defined as ≥70% luminal stenosis on CTA. EAT was quantified automatically as the total volume of tissue with -190 to -30 HU.Of 125 patients, 76 had SS. Between the patients with and without SS, there were significant differences in coronary artery calcium score (CACS), left ventricular ejection fraction (LVEF), dyslipidemia, and EAT, despite no differences in carotid echocardiography findings. After adjustment for age, gender, and dyslipidemia, EAT was an independent factor associated with SS (p=0.011), as well as CACS and LVEF. The addition of EAT to a baseline model including age, gender, dyslipidemia, LVEF, and CACS achieved both net reclassification improvement (0.505, p=0.003) and integrated discrimination improvement (0.059, p=0.003).In patients with carotid stenoses, EAT is associated with CAD and is useful for additional risk stratification. Epicardial fat may have a specific role in the development of CAD in patients with suspected systemic atherosclerosis.
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