Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma

DNA甲基化 表观遗传学 肿瘤科 淋巴瘤 前瞻性队列研究 医学 内科学 甲基化 免疫学
作者
Almudena Espín-Pérez,Kevin Brennan,Asiri Ediriwickrema,Olivier Gevaert,Izidore S. Lossos,A.J. Gentles
出处
期刊:npj precision oncology [Nature Portfolio]
卷期号:6 (1)
标识
DOI:10.1038/s41698-022-00295-3
摘要

Abstract Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Since patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes, accurate and sensitive methods for early detection are needed to improve patient care. We developed a DNA methylation-based prediction tool for NHL, based on blood samples collected prospectively from 278 apparently healthy patients who were followed for up to 16 years to monitor for NHL development. A predictive score was developed using machine learning methods in a robust training/validation framework. Our predictive score incorporates CpG DNA methylation at 135 genomic positions, with higher scores predicting higher risk. It was 85% and 78% accurate for identifying patients at risk of developing future NHL, in patients with high or low epigenetic mitotic clock respectively, in a validation cohort. It was also sensitive at detecting active NHL (96.3% accuracy) and healthy status (95.6% accuracy) in additional independent cohorts. Scores optimized for specific NHL subtypes showed significant but lower accuracy for predicting other subtypes. Our score incorporates hyper-methylation of Polycomb and HOX genes, which have roles in NHL development, as well as PAX5 - a master transcriptional regulator of B-cell fate. Subjects with higher risk scores showed higher regulatory T-cells, memory B-cells, but lower naïve T helper lymphocytes fractions in the blood. Future prospective studies will be required to confirm the utility of our signature for managing patients who are at high risk for developing future NHL.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
星辰大海应助兔子采纳,获得10
刚刚
hwy完成签到,获得积分10
刚刚
情怀应助W~舞采纳,获得10
1秒前
jiuli发布了新的文献求助10
1秒前
FashionBoy应助猪猪hero采纳,获得10
1秒前
小饼干发布了新的文献求助10
1秒前
霸气忙内完成签到,获得积分10
2秒前
2秒前
流离失所完成签到,获得积分10
3秒前
3秒前
3秒前
3秒前
传奇3应助闪闪的屁股采纳,获得10
4秒前
4秒前
爱宝乐宝福宝应助zz123采纳,获得20
4秒前
淡淡代玉发布了新的文献求助10
5秒前
Gilana发布了新的文献求助10
5秒前
BUHUIWAN完成签到,获得积分10
5秒前
余偲发布了新的文献求助10
6秒前
李佳倩发布了新的文献求助10
6秒前
秋风暖暖发布了新的文献求助10
6秒前
wy.he应助明亮紫易采纳,获得10
7秒前
blingbling发布了新的文献求助10
7秒前
吗喽完成签到,获得积分10
7秒前
李健应助TIGun采纳,获得30
7秒前
阮楷瑞发布了新的文献求助10
8秒前
汉堡包应助Bigbiglei采纳,获得10
8秒前
LZJ完成签到 ,获得积分10
9秒前
七七完成签到,获得积分10
10秒前
10秒前
羽宇发布了新的文献求助10
10秒前
haha发布了新的文献求助10
11秒前
11秒前
zhouyan完成签到,获得积分10
12秒前
海阔云高完成签到 ,获得积分10
13秒前
佛人世间完成签到,获得积分10
13秒前
14秒前
Menand完成签到,获得积分10
14秒前
U87发布了新的文献求助10
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974559
求助须知:如何正确求助?哪些是违规求助? 3518949
关于积分的说明 11196503
捐赠科研通 3255066
什么是DOI,文献DOI怎么找? 1797673
邀请新用户注册赠送积分活动 877076
科研通“疑难数据库(出版商)”最低求助积分说明 806130