磺胺噻唑
药代动力学
尿
药理学
性情
排泄
半衰期
化学
口服
药品
医学
生物化学
心理学
社会心理学
有机化学
作者
G. D. KORITZ,R F Bevill,David W. A. Bourne,Lewis W. Dittert
出处
期刊:PubMed
日期:1978-03-01
卷期号:39 (3): 481-4
被引量:10
摘要
Disposition of sulfathiazole in plasma and urine of swine was determined following single intravenous and oral doses. Pharmacokinetics of the drug were described by a 1-compartment open model. The drug was rapidly eliminated, mainly by renal excretion of unchanged sulfathiazole and metabolism to acetylsulfathiazole, with a biological half-life of 1.4 hours. Sulfathiazole (in solution) was absorbed rapidly (half-life 0.8 hour) and relatively completely (73%) following oral administration.
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