核苷酸还原酶
毒性
溶解循环
化学
激进的
作用机理
DNA损伤
生物化学
程序性细胞死亡
机制(生物学)
细胞生物学
细胞毒性
DNA
生物
细胞凋亡
体外
免疫学
有机化学
病毒
哲学
认识论
基因
蛋白质亚单位
作者
Waldemar M. Przybyszewski,Janusz Kasperczyk
摘要
It has been shown that hydroxyurea (HU) induces free radicals which exert cytotoxic effects on cells. However, the molecular mechanism of this effect is still obscure. A possible mechanism for HU-mediated cell death induced by unbalanced growth could be the overproduction, altered accumulation, and progressive leakage of many hydrolytic enzymes through the cell membrane, leading to lytic cell death. Protection by antioxidants and radicals scavengers does not change the inhibition of DNA synthesis dependent on ribonucleotide reductase, the main mechanism of the antineoplastic activity of HU. These observations support the hypothesis that membranes are targets for the side effects of HU toxicity. Damage of erythrocytes and granulocytes seems to be an important clinical feature of the HU side toxicity generating free radicals.
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