乙酰化
乙酰转移酶
赖氨酸
乙酰转移酶
生物化学
溴尿嘧啶
代谢组
代谢物
蛋白质组学
化学
翻译后修饰
蛋白质组
氨基酸
组蛋白乙酰转移酶
组蛋白
生物
酶
基因
作者
Adrian Drazic,Line M. Myklebust,Rasmus Ree,Thomas Arnesen
标识
DOI:10.1016/j.bbapap.2016.06.007
摘要
Acetylation is one of the major post-translational protein modifications in the cell, with manifold effects on the protein level as well as on the metabolome level. The acetyl group, donated by the metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either the α-amino group of the N-terminus of proteins or to the ε-amino group of lysine residues. These reactions are catalyzed by various N-terminal and lysine acetyltransferases. In case of lysine acetylation, the reaction is enzymatically reversible via tightly regulated and metabolism-dependent mechanisms. The interplay between acetylation and deacetylation is crucial for many important cellular processes. In recent years, our understanding of protein acetylation has increased significantly by global proteomics analyses and in depth functional studies. This review gives a general overview of protein acetylation and the respective acetyltransferases, and focuses on the regulation of metabolic processes and physiological consequences that come along with protein acetylation.
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