Anti-senescence effect of Cynomorium Songaricum polysaccharide on D-galactose-induced aging mice

OBJECTIVE The effect of Cynomorium Songaricum polysaccharide(CSP) on immune function was studied on the aged mice for CSP's applying for the clinical uses.METHODS Kunming mice were intraperitoneal injected with D-galactose to make the aging models,and different dosages of CSP were given by gavage for 56 days.Spleen coefficient and thymus coefficient were determined.MTT method was used to detect the proliferated number of the bone marrow cells.Lymphocyte transformation rate and peritoneal macrophage phagocytic rate in vivo were tested.The activity of telomerase in the testicles of the mile mice were detected by Elisa method.RESULTS Low,middle and high dosages of CSP could cause a significant increase of the proliferated number of the bone marrow cells in the aged mice (P0.01).High dosages of CSP could significantly increase the lymphocyte transformation rate(P0.01) and the peritoneal macrophage phagocytic rate(P0.05).High and middle dosages of CSP could significantly increase the activity of telomerase.CONCLUSION CSP can exert the anti-aging effect on the aging mice.