Production of multicolor or multiple wavelength lasers over the full visible-color spectrum from a single chip device has widespread applications, such as superbright solid-state lighting, color laser displays, light-based version of Wi-Fi (Li-Fi), and bioimaging, etc. However, designing such lasing devices remains a challenging issue owing to the material requirements for producing multicolor emissions and sophisticated design for producing laser action. Here we demonstrate a simple design and highly efficient single segment white random laser based on solution-processed NaYF4:Yb/Er/Tm@NaYF4:Eu core–shell nanoparticles assisted by Au/MoO3 multilayer hyperbolic meta-materials. The multicolor lasing emitted from core–shell nanoparticles covering the red, green, and blue, simultaneously, can be greatly enhanced by the high photonic density of states with a suitable design of hyperbolic meta-materials, which enables decreasing the energy consumption of photon propagation. As a result, the energy upconversion emission is enhanced by ∼50 times with a drastic reduction of the lasing threshold. The multiple scatterings arising from the inherent nature of the disordered nanoparticle matrix provide a convenient way for the formation of closed feedback loops, which is beneficial for the coherent laser action. The experimental results were supported by the electromagnetic simulations derived from the finite-difference time-domain (FDTD) method. The approach shown here can greatly simplify the design of laser structures with color-tunable emissions, which can be extended to many other material systems. Together with the characteristics of angle free laser action, our device provides a promising solution toward the realization of many laser-based practical applications.