Neuroanatomy, Dorsal Root Ganglion

Dorsal nerve roots carry sensory neural signals to the central nervous system (CNS) from the peripheral nervous system (PNS).The dorsal root ganglion (DRG) has a significant clinical application, particularly in its association with neuropathic pain. DRG neurons emerge from the dorsal root of the spinal nerves, carrying sensory messages from various receptors, including those for pain and temperature towards the central nervous system for a response.Until recently, the dorsal root ganglion has been considered a passive organ that metabolically assists functions and pathways between the PNS and CNS. New studies suggest, however, that the DRG is an active participant in peripheral processes, including PAF injury, inflammation, and neuropathic pain development. A proper understanding of the significance and functioning of the DRG can help improve the diagnosis and treatment of neuropathic pain syndromes.