GDF15型
胶质细胞源性神经生长因子
恶病质
能量稳态
内分泌学
生物
内科学
瘦素
神经营养因子
癌症
受体
医学
肥胖
作者
Vicky Wang-Wei Tsai,Yasmin Husaini,Amanda Sainsbury,David A. Brown,Samuel N. Breit
标识
DOI:10.1016/j.cmet.2018.07.018
摘要
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified receptor called glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which is a distant orphan member of the GDNF receptor family that signals through the tyrosine kinase receptor Ret. MIC-1/GDF15 expression and serum levels rise in response to many stimuli that initiate cell stress and as part of a wide variety of disease processes, most prominently cancer and cardiovascular disease. The best documented actions of MIC-1/GDF15 are on regulation of energy homeostasis. When MIC-1/GDF15 serum levels are substantially elevated in diseases like cancer, it subverts a physiological pathway of appetite regulation to induce an anorexia/cachexia syndrome initiated by its actions on hindbrain neurons. These effects make it a potential target for the treatment of both obesity and anorexia/cachexia syndromes, disorders lacking any highly effective, readily accessible therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI