Surgical Cleavage of Unstrained C(sp3)−C(sp3) Bonds in General Alcohols for Heteroaryl C−H Alkylation and Acylation

Abstract We reported herein a predictable and surgical cleavage of carbon‐carbon bond in alcohols. A wide range of 1°, 2° and 3° alcohols including sugars and steroids without ring strain or steric hindrance were all compatible with this system. Also it offered a green and practical strategy for generation of alkyl/acyl radicals using alcohols as the sources. Besides, the features of visible‐light‐initiation, catalyst and metal free, excellent selectivity and mild conditions make it valuable and attractive. magnified image