全基因组关联研究
牙齿磨损
遗传关联
队列
牙科
牙缺失
医学
生物
遗传学
基因
单核苷酸多态性
口腔健康
基因型
病理
作者
Viivi Alaraudanjoki,Salla Koivisto,Paula Pesonen,Minna Männikkö,Jukka Leinonen,Leo Tjäderhane,Marja-Liisa Laitala,Adrian Lussi,Vuokko Anttonen
出处
期刊:Caries Research
[S. Karger AG]
日期:2018-06-13
卷期号:53 (1): 49-59
被引量:7
摘要
Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the strongest genome-wide significant signals were observed in or near the genes FGFR1, C8orf86, CDH4, SCD5, F2R, and ING1. Additionally, multiple suggestive association signals were detected in all GWASs performed. Many of the signals were in or near the genes putatively related to oral environment or tooth development, and some were near the regions considered to be associated with dental caries, such as 2p24, 4q21, and 13q33. Replications of these associations in other samples, as well as experimental studies to determine the biological functions of associated genetic variants, are needed.
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