STW 3-VI (Hypericum perforatum L.) increases plasticity of hippocampal neurons, as well as the migration of microglia cells and inhibits oxLDL-induced ROS production

Depressive symptoms may be induced by chronic stressful life events, which affect the neuronal and microglia function. Microglia activation and remodeling of dendrites in the hippocampus are apparently relating to depression development and healing, but the molecular mechanism is not fully understood. Extracts of Hypericum perforatum L., like STW 3-VI have been recommended for the treatment of depression. The aim of our investigation was to determine in vitro the effects of STW 3-VI on neuronal plasticity and microglia functions.