Wnt信号通路
包装D1
常染色体显性多囊肾病
多囊肾病
癌症研究
生物
河马信号通路
连环蛋白
连环素
细胞生物学
信号转导
肾
内科学
内分泌学
医学
作者
Eun Ji Lee,Eunjeong Seo,Jin Won Kim,Sun Ah Nam,Jong‐Young Lee,Jaehee Jun,Sumin Oh,Minah Park,Eek‐hoon Jho,Kyung Hyun Yoo,Jong Hoon Park,Yong Kyun Kim
标识
DOI:10.1073/pnas.2009334117
摘要
Significance Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of PKD1 or PKD2 , leading to end-stage renal disease. There are few cures for ADPKD, although many researchers are trying to find a cure. The Hippo signaling pathway regulates organ growth and cell proliferation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a Hippo signaling effector. In this study, we demonstrated that the PKD1–TAZ–Wnt–β-catenin–c-MYC signaling axis plays a critical role in cystogenesis. Endo IWR1 treatment, which inhibited β-catenin activity via AXIN stabilization, reduced cyst growth in an ADPKD model. Our findings provide a potential therapeutic target against ADPKD and would be important for clinical translation.
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