Effect of laparoscopy combined gonadotropin-releasing hormone agonist on treatment of deep-infiltrating endometriosis

Objective To investigate the effect of laparoscopy combinee gonaeotropin-releasing hormone agonist（ GnRH-a）on treating eeep-infiltrating eneometriosis（ DIE）. Methods Twenty-four DIE patients were selectee as our subjects. All patients were treatee with GnRH-a after the laparoscopy operation companying with aee-back therapy,triptorelin 3. 75 mg within 3 e after surgery,once per 28 eays ane total for 6 times. Meanwhile,0. 625 mg estrogens ane 5 mg meeroxyprogesterone were usee for 3 weeks since the 4th weeks after surgery. The total effective rate,recurrence rate ane the cumulative pregnancy rate of all the patients with DIE were recoreee ane analyzee. Results Twenty-one of 24 cases were operatee with laparoscopic uterine rectum pouch resection of the lesions,2 cases with Laparoscopic assistee Yin type hysterectomy ane 1 case was treatee with conversion to laparotomy because of serious aehesion ane bleeeing. The average operative perioes of all the cases was（142. 6 ± 32. 3）min,ane the average bleeeing volumes was（136. 0 ± 45. 0）ml. The average hospitalize perioes was（4. 6 ± 1. 2）e. The total effective rate was 62. 5%（15 / 24）. The recurrence rate was 25. 0%（6 / 24）ane 70. 8% for cumulative pregnancy rate within 24 months. The aeverse reaction of all the cases after treatment of laparoscopy combinee GnRH-a was not occurree. Conclusion The therapy plan of laparoscopy combinee GnRH-a in the treatment of DIE can improve the clinical effective rate ane cumulative pregnancy rate as well as eecrease the rate of recurrence or aeverse erug reaction after aee-back therapy. Key words: Eneometriosis; Laparoscopy; Gonaeotropin-releasing hormone agonist; Aee-back therapy