过氧化氢酶
超氧化物歧化酶
氧化应激
细胞凋亡
化学
活性氧
生物化学
过氧化物酶
生物物理学
癌症研究
细胞生物学
酶
生物
作者
Zhongqiang Wang,Guoliang Li,Yang Gao,Ying Yu,Yang Pan,Bing Li,Xingkai Wang,Jinjian Liu,Kezheng Chen,Jianfeng Liu,Wei Wang
标识
DOI:10.1016/j.cej.2020.125574
摘要
Despite an ever-growing number of investigations and advances in nanozymes and oxidative stress anti-tumor therapy, nanoparticles capable of maintaining the redox balance as natural antioxidative system are scarce. Herein, iron phosphates -based (FePOs) nanozyme, was synthesized via a simple hydrothermal method. We first discovered that the FePOs nanozyme has trienzyme-like activities. It is peroxidase (POD)-like in acidic tumor microenvironment and can mediate a highly efficient FePOs + H2O2 anti-tumor protocol via catalyzing ·OH generation from H2O2. Quite different from any other reported nanozymes, at physiological pH the FePOs is not only catalase (CAT)-like but also superoxide dismutase (SOD)-like. It exerts combined SOD-CAT effects on normal tissues, which is analogous to the synergistic effects of natural SOD-CAT in living organisms, and hence protects normal tissues from injuries of the FePOs + H2O2 protocol. Apoptosis was found to be the pathway by which cancer cell death is induced by FePOs + H2O2. Notably, the FePOs + H2O2 protocol led to no abnormal behavior, significant weight loss or obvious adverse effects on normal tissues in mice as the results of the combined SOD-CAT effects. All these intriguing results confirm that the FePOs nanozyme is an excellent candidate for nanomedicine and holds promise for enhanced anti-tumor efficiency with minimal side effects.
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