随机对照试验
过滤(数学)
微粒
交叉研究
甲基化
双盲
化学
医学
免疫学
生物
内科学
DNA
生态学
病理
生物化学
统计
数学
安慰剂
替代医学
作者
Yanyan Sun,Jing Huang,Yan Zhao,Lijun Xue,Hongyu Li,Qisijing Liu,Han Cao,Wenjuan Peng,Chunyue Guo,Yunyi Xie,Xiaohui Liu,Bingxiao Li,Kuo Liu,Shaowei Wu,Ling Zhang
标识
DOI:10.1016/j.jhazmat.2020.122817
摘要
Benefits of indoor air filtration in heavily polluted areas are not fully understood. This study aims to examine whether short-term air filtration intervention could attenuate the hazards from acute exposure to fine particulate matter (PM2.5), and investigate the potential impact on inflammatory cytokines and DNA methylation. A randomized, double-blind crossover trial of true or sham indoor air filtration was conducted among 29 healthy young adults in Beijing, China. Each episode covered a typical air pollution wave, and 38 cytokines and DNAm of 20 genes were measured at 3 time points: pre-smog, during smog, and post-smog. Linear mixed-effect models were used to evaluate the associations. The indoor PM2.5 concentration with true filtration was 67.8 % lower than sham filtration (13.8 μg/m3vs. 42.8 μg/m3). Air filtration was significantly associated with the decreases in 9 cytokines, from 6.61 % to 21.24 %. PM2.5 exposure was significantly associated with elevated levels of 9 cytokines and changed methylation at 7 CpG sites. Notably, PM2.5 was significantly associated with GM-CSF, sCD40L, MCP-1, and FGF-2, as well as methylation in corresponding genes, but no mediation effect was observed. This trial suggested that indoor air filtration might attenuate the adverse effects of PM2.5 exposure through changing cytokines and DNAm.
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