Synthesis of 3‐Methylthioindolesvia Intramolecular Cyclization of 2‐Alkynylanilines Mediated by DMSO/DMSO‐d6 and SOCl2

Main observation and conclusion The intramolecular cyclization of 2‐alkynylanilines mediated by DMSO/SOCl 2 was found to afford biologically interesting 3‐methylthioindoles, which are rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated counterpart, enabling the method applicable to the construction of indole skeleton bearing a SCD 3 moiety at its 3‐position.