Effect of rosemary extract on the microstructure, phase evolution, and magnetic behavior of cobalt ferrite nanoparticles and its application on anti-cancer drug delivery

材料科学 纳米颗粒 扫描电子显微镜 核化学 透射电子显微镜 壳聚糖 生物相容性 磁性纳米粒子 化学工程 傅里叶变换红外光谱 分析化学(期刊) 纳米技术 色谱法 化学 复合材料 冶金 工程类
作者
Meysam Ghanbari,Fatemeh Davar,Ahmed Esmail Shalan
出处
期刊:Ceramics International [Elsevier]
卷期号:47 (7): 9409-9417 被引量:40
标识
DOI:10.1016/j.ceramint.2020.12.073
摘要

Cobalt ferrite nanoparticles (CFO NPs) were synthesized by a modified sol-gel method using Fe(NO3)3.9 H2O and Co(NO3)2·6H2O as the sources of Fe 3+ and Co 2+ in presence of different volumes of rosemary extract and sucrose as gel agent, chelating agent and non-magnetic elements such as calcium and magnesium ions. The prepared nanoparticles were characterized via X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The X-ray diffraction results confirmed that the sample prepared with 5 mL rosemary extract has single-phase spinel cobalt ferrite nanoparticles with a cubic crystal structure at 750 °C for 3 h (S1 sample). The average crystallite size was calculated about 33 nm using the Debye–Scherrer equation. Scanning electron microscopy also exposed that the prepared nanoparticles have a cubic morphology. Besides, the magnetic properties of the as-synthesized nanoparticles (S1 sample) indicated the highest saturated magnetization of 64 emu.g−1 as compared to other samples. The nanoparticles were then coated with tripolyphosphate (TPP) and chitosan polymer (Cs) to be applied as a carrier for drug delivery CoFe2O4-TPP-Cs (CFO-TPP-CS). The antioxidant doxorubicin (DOX) drug was then covered on the surface of the nanoparticles, and its drug release (CFO-TPP–CS–DOX) from the substrate of coated nanoparticles containing doxorubicin was evaluated at different pH levels. The coated CFO nanoparticles with tripolyphosphate (TPP) –Chitosan (Cs) sample indicated the biocompatibility and non-toxic nature of CFO-TPP- Cs NPs. Meanwhile, the CFO-TPP–CS–DOX nanosystem showed good death percentage of the breast cell cancer line (MCF-7 cell) in an acidic medium.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
积极的霸完成签到,获得积分10
刚刚
1秒前
2秒前
小二郎应助阿曼尼采纳,获得10
4秒前
张浩发布了新的文献求助10
5秒前
7秒前
王kk发布了新的文献求助10
9秒前
lewis17发布了新的文献求助30
9秒前
chenlang发布了新的文献求助30
11秒前
14秒前
荔枝完成签到,获得积分10
14秒前
aDou完成签到,获得积分10
15秒前
kaier完成签到 ,获得积分10
16秒前
吴旭东完成签到,获得积分10
18秒前
英俊的铭应助蛋黄啵啵采纳,获得10
18秒前
花痴的慕蕊完成签到,获得积分10
20秒前
21秒前
华仔应助健康的幻珊采纳,获得10
21秒前
清明完成签到,获得积分10
21秒前
Wei完成签到 ,获得积分10
21秒前
Lemon应助迷路的初柔采纳,获得10
23秒前
上好佳完成签到 ,获得积分10
23秒前
令狐绝音完成签到,获得积分10
24秒前
27秒前
30秒前
天使小五哥完成签到,获得积分0
30秒前
乐乐应助ZYL采纳,获得10
31秒前
哈哈完成签到,获得积分10
31秒前
Lu发布了新的文献求助10
32秒前
李振华发布了新的文献求助10
33秒前
鸭嘴兽完成签到,获得积分20
33秒前
34秒前
36秒前
顾矜应助李振华采纳,获得10
39秒前
40秒前
共享精神应助健康的幻珊采纳,获得10
42秒前
顾矜应助清明采纳,获得10
43秒前
44秒前
44秒前
ephore应助theonePTC采纳,获得30
45秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 600
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3064589
求助须知:如何正确求助?哪些是违规求助? 2719285
关于积分的说明 7463273
捐赠科研通 2365693
什么是DOI,文献DOI怎么找? 1254139
科研通“疑难数据库(出版商)”最低求助积分说明 608796
版权声明 596684