Effect of rosemary extract on the microstructure, phase evolution, and magnetic behavior of cobalt ferrite nanoparticles and its application on anti-cancer drug delivery

材料科学 纳米颗粒 扫描电子显微镜 核化学 透射电子显微镜 壳聚糖 生物相容性 磁性纳米粒子 化学工程 傅里叶变换红外光谱 分析化学(期刊) 纳米技术 色谱法 化学 复合材料 冶金 工程类
作者
Meysam Ghanbari,Fatemeh Davar,Ahmed Esmail Shalan
出处
期刊:Ceramics International [Elsevier]
卷期号:47 (7): 9409-9417 被引量:40
标识
DOI:10.1016/j.ceramint.2020.12.073
摘要

Cobalt ferrite nanoparticles (CFO NPs) were synthesized by a modified sol-gel method using Fe(NO3)3.9 H2O and Co(NO3)2·6H2O as the sources of Fe 3+ and Co 2+ in presence of different volumes of rosemary extract and sucrose as gel agent, chelating agent and non-magnetic elements such as calcium and magnesium ions. The prepared nanoparticles were characterized via X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The X-ray diffraction results confirmed that the sample prepared with 5 mL rosemary extract has single-phase spinel cobalt ferrite nanoparticles with a cubic crystal structure at 750 °C for 3 h (S1 sample). The average crystallite size was calculated about 33 nm using the Debye–Scherrer equation. Scanning electron microscopy also exposed that the prepared nanoparticles have a cubic morphology. Besides, the magnetic properties of the as-synthesized nanoparticles (S1 sample) indicated the highest saturated magnetization of 64 emu.g−1 as compared to other samples. The nanoparticles were then coated with tripolyphosphate (TPP) and chitosan polymer (Cs) to be applied as a carrier for drug delivery CoFe2O4-TPP-Cs (CFO-TPP-CS). The antioxidant doxorubicin (DOX) drug was then covered on the surface of the nanoparticles, and its drug release (CFO-TPP–CS–DOX) from the substrate of coated nanoparticles containing doxorubicin was evaluated at different pH levels. The coated CFO nanoparticles with tripolyphosphate (TPP) –Chitosan (Cs) sample indicated the biocompatibility and non-toxic nature of CFO-TPP- Cs NPs. Meanwhile, the CFO-TPP–CS–DOX nanosystem showed good death percentage of the breast cell cancer line (MCF-7 cell) in an acidic medium.
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