PvuII and XbaI in Estrogen Receptor 1 (ESR1) Polymorphisms and Susceptibility to Endometriosis Risk

雌激素受体α 子宫内膜异位症 雌激素受体 雌激素 内科学 医学 雌激素受体 内分泌学 乳腺癌 癌症
作者
Jingwen Wang,Rong Hu,Jingjing Wang,Qian He
出处
期刊:Clinical Laboratory [Clinical Laboratory Publications]
卷期号:66 (08/2020) 被引量:2
标识
DOI:10.7754/clin.lab.2020.191209
摘要

Studies have shown that variants in PvuII and XbaI loci are associated with the occurrence and progression of endometriosis (EM), while the results were in great debate.A systematic review and meta-analysis were conducted to evaluate the role of PvuII and XbaI polymor-phisms in estrogen receptors (ESR1). The primary sources of the reviewed studies through December 2018, with restriction on the language of English and Chinese, were Pubmed and Embase and CNKI. The pooled odds ratio 95% confidence intervals (CIs) were calculated to evaluate the associations of Pvull and Xbal polymorphisms with the risk of EM by using the STATA 14.0 software.A total of 18 studies with 4,975 patients, 2,222 in the case group, 2,753 in the control group, were in the final analysis. Overall pooled outcomes did not indicate significant correlations between the ESR1 Pvull/Xbal polymorphisms and the EM development. In subgroup analysis, PvuII was associated with endometriosis only for stage I - III and only under a recessive model (OR = 1.61, 95% CI: 1.03 to 2.07; p = 0.03). Xbal was associated with endometriosis only for the non-PCR-RFLP genotype method and also only under a recessive model (OR = 2.10, 95% CI: 1.21 to 4.47; p = 0.04).This present meta-analysis reported that polymorphisms of PvuII or Xbal were not related to the susceptibility to EM except for a slight association of stage I-III endometriosis and non-PCR-RFLP under recessive model. Future, well-designed large studies are eagerly awaited to confirm our conclusions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
yiming完成签到,获得积分10
1秒前
顾矜应助Elddis采纳,获得10
1秒前
2秒前
乐乐应助Yihua采纳,获得10
2秒前
添酱完成签到,获得积分20
2秒前
早点毕业完成签到 ,获得积分10
2秒前
Yeah完成签到,获得积分10
2秒前
情怀应助孝顺的碧琴采纳,获得10
3秒前
Wayne66发布了新的文献求助30
4秒前
王小茗完成签到,获得积分10
4秒前
4秒前
superbanggg发布了新的文献求助10
4秒前
完美世界应助奔跑的棉花采纳,获得10
5秒前
5秒前
喻天蓝发布了新的文献求助10
5秒前
Lily完成签到,获得积分10
5秒前
zzpj发布了新的文献求助10
5秒前
老迟到的灵煌完成签到,获得积分10
6秒前
风中清炎给风中清炎的求助进行了留言
7秒前
7秒前
海昌完成签到 ,获得积分10
7秒前
7秒前
7秒前
8秒前
Able完成签到,获得积分10
8秒前
9秒前
9秒前
完美世界应助小田睡不醒采纳,获得10
9秒前
9秒前
9秒前
现实世界npc完成签到,获得积分10
10秒前
美丽松鼠发布了新的文献求助10
10秒前
Mok完成签到,获得积分10
10秒前
11秒前
13秒前
舒服的荆发布了新的文献求助10
13秒前
13秒前
Mok发布了新的文献求助10
14秒前
zzpj完成签到,获得积分10
14秒前
高分求助中
Evolution 10000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3147695
求助须知:如何正确求助?哪些是违规求助? 2798784
关于积分的说明 7831337
捐赠科研通 2455622
什么是DOI,文献DOI怎么找? 1306889
科研通“疑难数据库(出版商)”最低求助积分说明 627943
版权声明 601587