Triblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics

Noncovalent encapsulation of multiple guest molecules with distinct physiochemical properties, especially hydrophilic and hydrophobic guests, into a single polymeric nanoassembly is challenging, but would be profoundly beneficial to combine with therapeutic delivery strategies. Here, we report a nanocomposite coassembled by coating a layer of an amphiphilic block copolymer onto the surface of a cross-linked inverse micelle driven by hydrophobic interactions. The hydrophobic coating layer and water-filled inverse micelles were utilized to encapsulate hydrophobic and hydrophilic cargos, respectively. Rationally introducing the pH and redox responsive moieties into the coating polymer and inverse micelles allows to sequentially address the triggered release of the encapsulated cargos.