免疫系统
生物
造血
表观基因组
细胞生物学
获得性免疫系统
电池类型
先天免疫系统
表观遗传学
染色质
转录组
髓样
干细胞
免疫学
细胞
DNA甲基化
基因
遗传学
基因表达
作者
Thomas Krausgruber,Nikolaus Fortelny,Victoria Gernedl,Martin Senekowitsch,Linda C. Schuster,Alexander Lercher,Amelie Nemc,Christian Schmidl,André F. Rendeiro,Andreas Bergthaler,Christoph Bock
出处
期刊:Nature
[Springer Nature]
日期:2020-07-01
卷期号:583 (7815): 296-302
被引量:316
标识
DOI:10.1038/s41586-020-2424-4
摘要
The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens1. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity2. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3–5. To advance our understanding of immunology outside the haematopoietic system, here we systematically investigate the regulation of immune genes in the three major types of structural cells: epithelium, endothelium and fibroblasts. We characterize these cell types across twelve organs in mice, using cellular phenotyping, transcriptome sequencing, chromatin accessibility profiling and epigenome mapping. This comprehensive dataset revealed complex immune gene activity and regulation in structural cells. The observed patterns were highly organ-specific and seem to modulate the extensive interactions between structural cells and haematopoietic immune cells. Moreover, we identified an epigenetically encoded immune potential in structural cells under tissue homeostasis, which was triggered in response to systemic viral infection. This study highlights the prevalence and organ-specific complexity of immune gene activity in non-haematopoietic structural cells, and it provides a high-resolution, multi-omics atlas of the epigenetic and transcriptional networks that regulate structural cells in the mouse. Structural cells implement a broad range of immune-regulatory functions beyond their roles as barriers and connective tissues, and they utilize an epigenetically encoded potential for immune gene activation in their rapid response to viral infection.
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