表面等离子共振
材料科学
生物传感器
葡萄糖氧化酶
光纤传感器
聚二甲基硅氧烷
温度测量
光纤
光电子学
分析物
分析化学(期刊)
纤维
光学
纳米技术
纳米颗粒
化学
色谱法
物理
复合材料
量子力学
作者
Shengnan Wu,Qin Tan,Erik Forsberg,Siqi Hu,Sailing He
出处
期刊:Optics Express
[The Optical Society]
日期:2020-07-06
卷期号:28 (14): 21046-21046
被引量:28
摘要
External temperature variations inevitably affect the accuracy of surface plasmon resonance (SPR) biosensors. To that end, we propose an ultra-compact label-free dual-channel SPR fiber sensor (DSPRFS) that can simultaneously measure the glucose concentration and ambient temperature in real-time. The proposed sensor is based on a unique dual-channel structure fabricated by etching a side-hole fiber (SHF), and has significantly higher spatial sensitivity than traditional SPR biosensors. After coating with silver and zinc oxide films, one channel was filled with polydimethylsiloxane (PDMS) to sense the ambient temperature, and the other channel was immobilized with glucose oxidase (GOx) enzyme for glucose sensing. The proposed sensor is analyzed theoretically, fabricated and characterized. Glucose concentration sensitivity and temperature sensitivity of the manufactured sensor sample were found to be as high as 6.156 nm / mM and -1.604 nm / °C with limits of detection (LOD) of 16.24 µM and 0.06 °C , respectively. The proposed sensor has an extremely compact structure, enables temperature compensation, and is suitable for in-situ monitoring and high-precision sensing of glucose and other biological analytes.
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