[Expression of immunological and inflammatory biomarkers in chronic rhinosinusitis with nasal polyps and its predictive value for recurrence].

医学 鼻息肉 内科学 慢性鼻-鼻窦炎 胃肠病学 接收机工作特性 哮喘 预测值 鼻窦炎 外科
作者
Ming Zheng,Min Wang,Ying Li,Xiangdong Wang,Luo Zhang
出处
期刊:PubMed 卷期号:54 (3): 174-180 被引量:6
标识
DOI:10.3760/cma.j.issn.1673-0860.2019.03.003
摘要

Objective: To evaluate the expression of immunological and inflammatory biomarkers as well as to analyze their predictive value for recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: Seventy-seven CRSwNP patients were enrolled in this survey from January 2011 to December 2012 in Beijing Tongren Hospital. There were 13 males and 64 females, with the range of age from 14 to 74 years old. The average follow-up period was more than 2 years. The demographic and clinical features of patients were compared between recurrence and non-recurrence groups, and 43 kinds of cytokines, chemokines and inflammatory mediators, tissue and serum total IgE, and morphological and cytology indexes were compared between the two groups. The receiver operating characteristic (ROC) curves were used to evaluate the predictive value of significant indicators for the postoperative recurrence of CRSwNP and to calculate the best diagnostic cut-off values. Results: The recurrence rate of CRSwNP was 44.2% (34/77). Compared with non-recurrence CRSwNP, there were higher risk of aspirin intolerance and asthma in the recurrence group, as well as higher CT and endoscopic polyp scores and lower olfactory sense (7/34 vs 0/43, 10/34 vs 4/43, 18.5[3.0, 24.0] vs 13.8[2.0, 24.0], 2.1[0.5, 3.0] vs 1.5[0.5, 3.0], 5.0[4.5, 5.0] vs 3.0[1.0, 5.0], χ(2) value was 9.738, 5.161, Z value was -3.267, -2.705, -3.213, respectively, all P<0.05). At the same time, the level of interleukin-5 (IL-5), eosinophilic cationic protein / myeloperoxidase (ECP/MPO), tissue inhibitor of metalloproteinase 1 (TIMP1), chemokine (C-C motif) ligand 2 (CCL2), CCL3, CCL4 and tissue and serum total IgE were higher in the recurrence group than those of the non-recurrence. Moreover, the oedema of the lamina propria were more severe. The total IgE, IL-5, ECP/MPO and CCL4 in the tissue had a acceptable discrimination value for the prediction of CRSwNP recurrence. The best diagnostic cut-off values and corresponding sensitivity and specificity were 124.85 pg/ml (82.4%, 60.5%), 6.22 pg/ml (76.5%, 58.1%), 0.61 (55.9%, 83.7%) and 2 456.96 pg/ml (61.8%, 79.1%), respectively. Conclusions: The profile of the immunological and inflammatory biomarkers was different between the non-recurrence CRSwNP and recurrence CRSwNP groups. And a variety of biomarkers can be considered as indicators of recurrence of CRSwNP with acceptable predictive value.目的: 研究慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)的免疫炎性因子表达特点,并探讨上述因子对患者术后复发的预测价值。 方法: 收集2011年1月至2012年12月就诊于北京同仁医院的77例CRSwNP患者,男性13例,女性64例,年龄14~74岁。随访2年以上,比较术后复发和未复发患者的人口学特征和临床特征,并比较其43种细胞因子、趋化因子、炎性介质、组织和血清中总IgE以及组织病理学差异。应用受试者工作特征(receiver operating characteristic,ROC)曲线评估差异有统计学意义的检测指标对CRSwNP术后复发的预测价值。 结果: CRSwNP患者术后复发率为44.2%(34/77)。复发与未复发的CRSwNP患者相比,伴发阿司匹林过敏和哮喘的比例、CT评分和内镜息肉评分均更高,嗅觉减退更明显[7/34比0/43,10/34比4/43,18.5[3.0,24.0]分(M[P(25),P(75)],下同)比13.8[2.0,24.0]分,2.1[0.5,3.0]分比1.5[0.5,3.0]分,5.0[4.5,5.0]分比3.0[1.0,5.0]分,χ(2)值分别为9.738、5.161,Z值分别为-3.267、-2.705、-3.213,P值均<0.05]。复发者组织中的白细胞介素5(IL-5)、嗜酸性阳离子蛋白/髓过氧化物酶(ECP/MPO)、基质金属蛋白酶抑制剂1(TIMP1)、趋化因子(CCL)2、CCL3、CCL4、组织和血清总IgE含量均高于未复发组,固有层水肿程度更重。组织中总IgE、IL-5、ECP/MPO和CCL4对CRSwNP复发具有可接受程度的预测价值,最佳诊断临界值和相应的敏感度、特异度分别为124.85 pg/ml(82.4%,60.5%)、6.22 pg/ml(76.5%,58.1%)、0.61(55.9%,83.7%)和2 456.96 pg/ml(61.8%,79.1%)。 结论: 复发和未复发CRSwNP术前鼻息肉组织的免疫炎性因子表达有不同特点,多种因子可作为预测CRSwNP术后复发与否的标志物。.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
彩色的芝麻完成签到 ,获得积分10
刚刚
Young完成签到,获得积分10
1秒前
迷途灯光完成签到,获得积分10
2秒前
夏夏夏完成签到,获得积分10
3秒前
Q22发布了新的文献求助10
3秒前
Lucas应助宝宝熊的熊宝宝采纳,获得10
3秒前
3秒前
3秒前
4秒前
科研顺风发布了新的文献求助10
4秒前
脑洞疼应助1s采纳,获得10
5秒前
lsw完成签到,获得积分10
5秒前
5秒前
dypdyp应助书枫哥哥采纳,获得10
5秒前
贰鸟完成签到,获得积分0
6秒前
HZY完成签到,获得积分20
6秒前
叶梓轩完成签到 ,获得积分10
6秒前
爱听歌婴发布了新的文献求助10
6秒前
恋恋青葡萄完成签到,获得积分10
7秒前
mxq完成签到,获得积分10
7秒前
lllll完成签到,获得积分10
7秒前
rain完成签到,获得积分10
7秒前
橘子完成签到,获得积分10
8秒前
123发布了新的文献求助10
8秒前
8秒前
Omsmall完成签到,获得积分10
8秒前
9秒前
隐形曼青应助顺利鹤采纳,获得10
9秒前
haihuhu完成签到 ,获得积分10
9秒前
HZY发布了新的文献求助10
9秒前
10秒前
10秒前
10秒前
10秒前
小超人完成签到,获得积分20
10秒前
LSY完成签到,获得积分10
11秒前
abby123完成签到,获得积分10
11秒前
11秒前
choi发布了新的文献求助10
11秒前
卓梨完成签到 ,获得积分10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969060
求助须知:如何正确求助?哪些是违规求助? 3513962
关于积分的说明 11171223
捐赠科研通 3249302
什么是DOI,文献DOI怎么找? 1794772
邀请新用户注册赠送积分活动 875377
科研通“疑难数据库(出版商)”最低求助积分说明 804769