催化作用
卟啉
单层
超分子化学
化学
纳米技术
纳米颗粒
材料科学
分子
组合化学
光化学
有机化学
作者
Roberto Cao‐Milán,S. Gopalakrishnan,Luke D. He,Rui Huang,Lisheng Wang,Laura Castellanos,David C. Luther,Ryan F. Landis,Jessa Marie Makabenta,Cheng‐Hsuan Li,Xianzhi Zhang,Federica Scaletti,Richard W. Vachet,Vincent M. Rotello
出处
期刊:Chem
[Elsevier]
日期:2020-05-01
卷期号:6 (5): 1113-1124
被引量:60
标识
DOI:10.1016/j.chempr.2020.01.015
摘要
Bio-orthogonal catalysis has the capability of localized generation of imaging and therapeutic molecules in vitro and in vivo. The integration of these catalysts into thermoresponsive nanoparticle platforms would generate bio-orthogonal “nanozymes” that could be controlled through endogenous or exogenous thermal control. We have fabricated thermoresponsive nanozymes by confining supramolecular assemblies of porphyrins into the monolayer of gold nanoparticles. The resulting nanodevices feature an on-off gated thermal response occurring over a 3°C range with commensurate tunability of activation temperature from 25°C to 37°C. Reversible activation of catalysis was demonstrated in complex biological environments, and the efficacy of bi-stable thermoresponsive nanozymes demonstrated through thermal activation of antibiotic-based prodrugs to effectively treat bacterial biofilms.
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