N6-甲基腺苷
功能(生物学)
核糖核酸
生物
化学
计算生物学
遗传学
甲基转移酶
基因
甲基化
作者
Zhansheng Zhu,Fu‐Chun Huo,Dong‐Sheng Pei
摘要
N6-methyladenosine (m 6 A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate.m 6 A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m 6 A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers).Accumulating evidence shows that m 6 A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses.In this review, we mainly summarize and discuss the functional relevance and importance of m 6 A modification in cellular processes.
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