嘧啶代谢
代谢物
代谢组学
尿素循环
泌尿系统
代谢途径
接收机工作特性
代谢组
结直肠癌
新陈代谢
曲线下面积
医学
化学
癌症
内科学
尿
代谢综合征
生物化学
精氨酸
色谱法
氨基酸
酶
嘌呤
作者
Yu Cheng,Guoxiang Xie,Tianlu Chen,Yunping Qiu,Xia Zou,Minhua Zheng,Binbin Tan,Bo Feng,Taotao Dong,Pingang He,Linjing Zhao,Aihua Zhao,Lisa X. Xu,Yan Zhang,Jia Wang
摘要
A full spectrum of metabolic aberrations that are directly linked to colorectal cancer (CRC) at early curable stages is critical for developing and deploying molecular diagnostic and therapeutic approaches that will significantly improve patient survival. We have recently reported a urinary metabonomic profiling study on CRC subjects (n = 60) and health controls (n = 63), in which a panel of urinary metabolite markers was identified. Here, we report a second urinary metabonomic study on a larger cohort of CRC (n = 101) and healthy subjects (n = 103), using gas chromatography time-of-flight mass spectrometry and ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry. Consistent with our previous findings, we observed a number of dysregulated metabolic pathways, such as glycolysis, TCA cycle, urea cycle, pyrimidine metabolism, tryptophan metabolism, polyamine metabolism, as well as gut microbial-host co-metabolism in CRC subjects. Our findings confirm distinct urinary metabolic footprints of CRC patients characterized by altered levels of metabolites derived from gut microbial-host co-metabolism. A panel of metabolite markers composed of citrate, hippurate, p-cresol, 2-aminobutyrate, myristate, putrescine, and kynurenate was selected, which was able to discriminate CRC subjects from their healthy counterparts. A receiver operating characteristic curve (ROC) analysis of these markers resulted in an area under the receiver operating characteristic curve (AUC) of 0.993 and 0.998 for the training set and the testing set, respectively. These potential metabolite markers provide a novel and promising molecular diagnostic approach for the early detection of CRC.
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