基因亚型
选择性拼接
同源染色体
RNA剪接
多样性(政治)
生物
差速器(机械装置)
拼接因子
遗传学
计算生物学
细胞生物学
基因
核糖核酸
政治学
工程类
航空航天工程
法学
作者
Ignacio Muñoz-Sanjuán,Philip M. Smallwood,Jeremy Nathans
标识
DOI:10.1074/jbc.275.4.2589
摘要
Fibroblast growth factor (FGF) homologous factors-1, -2, -3, and -4 (FHFs 1–4; also referred to as FGFs 11–14) comprise a separate branch of the FGF family and have been implicated in the development of the nervous system and limbs. We report here the characterization of multiple isoforms of FHF-1, -2, -3, and -4 which are generated through the use of alternative start sites of transcription and splicing of one or more of a series of alternative 5′-exons. Several isoforms show different subcellular distributions when expressed in transfected tissue culture cells, and the corresponding differentially spliced transcripts show distinct expression patterns in developing and adult mouse tissues. Together with the evolutionary conservation of the FHF isoforms among human, mouse, and chicken, these data indicate that alternative promoter use and differential splicing are important regulatory processes in controlling the activities of this subfamily of FGFs.
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