Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women

STEOPOROSIS IS ASSOCIated with significant morbidity and mortality. 1,24][5] Although randomized trials have shown that treatment with bisphosphonates reduces the risk of osteoporotic fractures, [6][7][8] concerns have recently emerged that bisphosphonate-related suppression of bone remodeling may adversely influence bone strength. 9n increasing number of case reports describe women who develop fractures involving the subtrochanteric or shaft region of the femur in the setting of long-term bisphosphonate therapy, generally after minimal trauma. 10Fractures at these sites are often described as atypical because of their location and characteristic radiographic appearance. 9,10The US