三苯氧胺
医学
耐受性
乳腺癌
肿瘤科
芳香化酶
内科学
男性乳腺癌
抗雌激素
妇科
癌症
不利影响
作者
Mark Clemons,Sarah Danson,Anthony Howell
标识
DOI:10.1016/s0305-7372(02)00036-1
摘要
Tamoxifen has been used in the management of breast cancer for over 30 years. Since its introduction for the treatment of advanced breast cancer, its indications have increased to include the treatment of early breast cancer, ductal carcinoma in situ, and more recently for breast cancer chemoprevention. Tamoxifen has a good tolerability profile and moreover, unlike many other endocrine therapies, it is efficacious in both pre- and postmenopausal women. It is the combination of efficacy and tolerability that allows tamoxifen to maintain its position as the hormonal treatment of choice for most patients with oestrogen-receptor positive breast cancer. Ongoing studies will provide further information about the optimal duration of tamoxifen therapy and how it compares with the newer aromatase inhibitors.
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