贝利婴儿发育量表
精神运动学习
母乳喂养
医学
婴儿发育
儿科
儿童发展
智力发展
百分位
环境卫生
心理学
发展心理学
认知
精神科
统计
数学
作者
Jens Walkowiak,J A Wiener,Anna Fastabend,Birger Heinzow,Ursula Krämer,Eberhard Schmidt,H J Steingrüber,S Wundram,Gerhard Winneke
出处
期刊:The Lancet
[Elsevier]
日期:2001-11-01
卷期号:358 (9293): 1602-1607
被引量:348
标识
DOI:10.1016/s0140-6736(01)06654-5
摘要
Background There is uncertainty whether environmental levels of exposure to polychlorinated biphenyls (PCBs) adversely affect mental and motor development in early childhood. We aimed to establish whether such an effect is of only prenatal or additional postnatal origin, and if a favourable home environment can counteract this effect. Methods Between 1993 and 1995 we recruited 171 healthy mother-infant pairs and prospectively measured psychodevelopment in newborn infants aged 7, 18, 30, and 42 months. We estimated prenatal and perinatal PCB exposure of newborn babies in cord blood and maternal milk. At 42 months we measured postnatal PCB concentrations in serum. At 18 months the quality of the home environment was assessed using the Home Observation for Measurement of the Environment scale. Mental and psychomotor development of the children were assessed using the Bayley Scales of Infant Development until 30 months and the Kaufman Assessment Battery for Children at 42 months. Findings Negative associations between milk PCB and mental/motor development were reported at all ages, becoming significant from 30 months onwards. Over 30 months, for a PCB increase from 173 (5th percentile) to 679 ng/g lipids in milk (95th percentile) there was a decrease of 8·3 points (95% Cl −16·5 to 0·0) in the Bayley Scales of Infant Development mental scores, and a 9·1 point decrease (95% Cl −17·2 to −1·02) in the Bayley Scales of Infant Development motor scores. There was also a negative effect of postnatal PCB exposure via breastfeeding at 42 months. Home environment had a positive effect from 30 months onwards (Bayley Scales of Infant Development mental score increase of 9·4 points [95% Cl 2·2−16·7]). Interpretation Prenatal PCB exposure at current European background levels inhibits, and a favourable home environment supports, mental and motor development until 42 months of age. PCB exposure also has an effect postnatally.
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