小胶质细胞
主要组织相容性复合体
干扰素γ
免疫系统
生物
免疫学
抗原
抗原呈递
细胞因子
干扰素
抗原处理
MHC I级
T细胞
炎症
作者
Jun Koyama,Tetsuya Mizuno,Hideyuki Takeuchi,Hiroaki Kato,J Wang,Norimasa Mitsuma,Akio Suzumura
标识
DOI:10.1177/1352458506070763
摘要
Neural cells do not usually interact with immune cells because of the lack of major histocompatibility complex (MHC) antigen expression. Interferon-gamma (IFN-gamma) enables this interaction via induction of MHC antigen expression in neural cells. Thus, IFN-gamma is a critical cytokine for the development of central nervous system (CNS) pathologies. IFN-gamma, however, is considered to be produced exclusively by lymphoid cells. Here, we show for the first time that murine microglia produce IFN-gamma in response to IL-12 and/or IL-18, using RT-PCR detection of IFN-gamma mRNA and Western blotting and immunohistochemical analysis for cytoplasmic expression of IFN-gamma. Stimulation of microglia with IL-12 and IL-18 resulted in MHC class II mRNA expression in microglia. Since IL-12 and IL-18 are produced in the CNS by glial cells, these cytokines may play a critical role in the initiation of neural-immune cell interaction and the induction of autoimmune processes in the CNS via induction of IFN-gamma and MHC antigens.
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