共聚物
表面改性
大分子单体
高分子化学
乙二醇
材料科学
衣康酸
PLGA公司
乙醇酸
聚合
化学工程
化学
有机化学
聚合物
乳酸
纳米颗粒
纳米技术
复合材料
生物
细菌
遗传学
工程类
作者
Lenka Michlovská,Lucy Vojtová,Ludmila Mravcová,Soňa Hermanová,Jiří Kučerík,Josef Jančář
标识
DOI:10.1002/masy.200900071
摘要
Abstract Summary: Biodegradable thermosensitive triblock copolymers based on poly(ethylene glycol) and poly(lactic‐ co ‐glycolic acid) (PLGA‐PEG‐PLGA) prepared via ring opening polymerization were modified by itaconic anhydride (ITA), which gives copolymer both reactive double bonds and functional carboxylic acid groups essential for the reaction with biological active material. Functionalization conditions comprising ITA purification, temperature, time and presence of solvent were optimized with the respect to amount of end‐capped ITA. Maximum of 76.6 mol. % of bonded ITA were reached via “one pot” reaction in a bulk at 110 °C after 1.5 h. ITA functionalization thermally stabilized the original copolymer by increasing the initial degradation temperature T d from 284 °C to 294 °C and changing the negative glass transition temperature ( T g = ‐1.8 °C) to positive one up to 2.4 °C. The novel functionalized macromonomer can be cross‐linked either chemically or physically in order to produce new functionalized hydrogel network applicable as biomedical material in tissue engineering.
科研通智能强力驱动
Strongly Powered by AbleSci AI