医学
优势比
肺癌
置信区间
内科学
病例对照研究
腺癌
小细胞癌
队列
相对风险
人口
队列研究
癌症
逻辑回归
人口学
胃肠病学
肺结核
病理
环境卫生
社会学
作者
Sung Sup Park,Lisa Y. Cho,Jae Jeong Yang,Boyoung Park,Soung Hoon Chang,Kun-Sei Lee,Hyeongsu Kim,Keun‐Young Yoo,Choon‐Taek Lee
出处
期刊:Lung Cancer
[Elsevier]
日期:2010-04-01
卷期号:68 (1): 20-26
被引量:69
标识
DOI:10.1016/j.lungcan.2009.05.017
摘要
We examined whether the strength of the association of cigarette smoking differs according to histological type and gender, and assessed other risk factors, in particular, tuberculosis. We recruited cases from the Korean Academy of Tuberculosis and Respiratory Diseases and controls from Chungju, a local site of the Korean Multi-Center Cancer Cohort. We matched one case to one control for females and two cases to one control for males according to age (≤44, 45–69, and ≥70 years old). We used unconditional logistic regression to calculate the odds ratio (OR) and 95% confidence interval (CI) to estimate lung cancer risk by histologic type for males and females separately. The OR (95% CI) of 40 or more pack-years smoked relative to never smokers was 6.78 (4.17–11.00), 3.49 (1.83–6.33), and 2.72 (1.57–4.72) for males, and 13.72 (3.23–58.18), 12.18 (3.12–47.57), and 7.11 (1.78–28.43) for females for squamous cell, adenocarcinoma, and small cell carcinoma, respectively. Among males, the respective OR (95% CI) for past and current history of lung tuberculosis was 3.21 (2.12–4.90), 2.69 (1.63–4.45), and 1.52 (0.83–2.78), and for females was 2.40 (1.30–4.42), 4.20 (2.75–6.39), and 1.37 (0.61–3.06). Our findings provide additional evidence that women are more susceptible to the carcinogenic effects of tobacco, smoking has a higher risk for squamous cell and small cell carcinoma than adenocarcinoma, and tuberculosis is a potential risk factor for certain lung cancer histologic types.
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