非诺贝特
氧化应激
内分泌学
肾
内科学
炎症
医学
纤维化
药理学
化学
作者
Xiaoyang Hou,Ying H. Shen,Chuanbao Li,Fei Wang,Cheng Zhang,Peili Bu,Yun Zhang
标识
DOI:10.1016/j.bbrc.2010.03.043
摘要
Oxidative stress has been shown to play an important role in the development of hypertensive renal injury. Peroxisome proliferator-activated receptors α (PPARα) has antioxidant effect. In this study, we demonstrated that fenofibrate significantly reduced proteinuria, inflammatory cell recruitment and extracellular matrix (ECM) proteins deposition in the kidney of SHRs without apparent effect on blood pressure. To investigate the mechanisms involved, we found that fenofibrate treatment markedly reduced oxidative stress accompanied by reduced activity of renal NAD(P)H oxidase, increased activity of Cu/Zn SOD, and decreased phosphorylation of p38MAPK and JNK in the kidney of SHRs. Taken together, fenofibrate treatment can protect against hypertensive renal injury without affecting blood pressure by inhibiting inflammation and fibrosis via suppression of oxidative stress and MAPK activity.
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