PTEN公司
张力素
PI3K/AKT/mTOR通路
磷酸酶
生物
抑制器
细胞生物学
功能(生物学)
癌症研究
雷帕霉素的作用靶点
蛋白激酶B
磷酸化
信号转导
癌症
遗传学
作者
Min Sup Song,Leonardo Salmena,Pier Paolo Pandolfi
摘要
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation by non-coding RNAs, post-translational modifications and protein-protein interactions, are all altered in cancer. The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus. Our increasing knowledge of PTEN and pathologies in which its function is altered will undoubtedly inform the rational design of novel therapies.
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