内皮功能障碍
医学
高血压的病理生理学
内皮
内科学
重症监护医学
心脏病学
平衡
血压
生物信息学
生物
作者
Kodlipet Dharmashankar,Michael E. Widlansky
标识
DOI:10.1007/s11906-010-0150-2
摘要
Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events and portends future cardiovascular risk. This review concentrates on recent findings with respect to the mechanisms of hypertension-associated endothelial dysfunction, the interrelationship between these two entities, and the relationship of the efficacy of antihypertensive therapies to improvements in vascular homeostasis beyond blood pressure reduction. Current evidence suggests that hypertension and endothelial dysfunction are integrally related with respect to pathophysiologic mechanisms. Future studies will need to identify the key connections between hypertension and endothelial dysfunction to allow novel interventions to be designed and promulgated.
科研通智能强力驱动
Strongly Powered by AbleSci AI